The existence of abundant interfaces in nanostructured materials makes it possible to reveal interfacial diffusion kinetics and relative characteristics (e.g., interfacial structure and phase transformation) at lower temperatures when diffusion proceeds in accordance to Harrison’s C-type regime. In this talk, the interfacial diffusion behavior in different nanostructured materials will be reviewed, including in gradient nanostructured and mixed nanostructured metals with different grain sizes and interfaces prepared by surface mechanical attrition treatment and dynamic plastic deformation, respectively, in ultra-fine grained materials produced by severe plastic deformation, and in nanostructured materials produced by inert gas condensation and consolidation, et al.. Distinct dependences of diffusion kinetics on sample preparation method and interfacial structure are revealed. The underlying mechanisms of such dependences will be discussed subsequently.